The longstanding, successful use of herbal drug combinations in traditional medicine makes it necessary to find a rationale for the pharmacological and therapeutic superiority of many of them in comparison to isolated single constituents. This review describes many examples of how modern molecular–biological methods (including new genomic technologies) can enable us to understand the various synergistic mechanisms underlying these effects.
Wagner, Hildebert. (2010). Synergy research: Approaching a new generation of phytopharmaceuticals. Fitoterapia. 82. 34-7. 10.1016/j.fitote.2010.11.016.
The seminal paper on the “entourage effect” describes how the ‘entourage effect’ may represent a novel route for molecular regulation of endogenous cannabinoid activity.
Ben-Shabat, Shimon & Fride, Ester & Sheskin, Tzviel & Tamiri, Tsippy & Rhee, Man & Vogel, Zvi & Bisogno, Tiziana & De petrocellis, Luciano & Di Marzo, Vincenzo & Mechoulam, Raphael. (1998). An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. European Journal of Pharmacology. 353. 23-31. 10.1016/S0014-2999(98)00392-6.
Topical film forming systems are such developing drug delivery systems meant for topical application to the skin, which adhere to the body, forming a thin transparent film and provide delivery of the active ingredients to the body tissue. These are intended for skin application as emollient or protective and for local action or transdermal penetration of medicament for systemic action.The transparency is an appreciable feature of this polymeric system which greatly influences the patient acceptance. In the current discussion, the film forming systems are described as a promising choice for topical and transdermal drug delivery.
Kashmira Kathe, Harsha Kathpalia, Film forming systems for topical and transdermal drug delivery, In Asian Journal of Pharmaceutical Sciences, Volume 12, Issue 6, 2017, Pages 487-497, ISSN 1818-0876, 10.1016/j.ajps.2017.07.004.
Pharmaceutical scientists throughout the world are trying to explore thin films as a novel drug delivery tool. Thin films have been identified as an alternative approach to conventional dosage forms. The thin films are considered to be convenient to swallow, self-administrable, and fast dissolving dosage form, all of which make it as a versatile platform for drug delivery. This delivery system has been used for both systemic and local action via several routes such as oral, buccal, sublingual, ocular, and transdermal routes. Use of thin films is sometimes limited largely due to low drug loading capacity for a less potent drug given at high dose. Also, concerns for medication precision have been raised. CURE has solved for this.
Karki, Sandeep & Kim, Hyeongmin & Na, Seon-Jeong & Shin, Dohyun & Jo, Kanghee & Lee, Jaehwi. (2016). Thin films as an emerging platform for drug delivery. Asian Journal of Pharmaceutical Sciences. 11. . 10.1016/j.ajps.2016.05.004.