White Papers

An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity

The seminal paper on the “entourage effect” describes how the ‘entourage effect’ may represent a novel route for molecular regulation of endogenous cannabinoid activity.

Ben-Shabat, Shimon & Fride, Ester & Sheskin, Tzviel & Tamiri, Tsippy & Rhee, Man & Vogel, Zvi & Bisogno, Tiziana & De petrocellis, Luciano & Di Marzo, Vincenzo & Mechoulam, Raphael. (1998). An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. European Journal of Pharmacology. 353. 23-31. 10.1016/S0014-2999(98)00392-6.

Synergy research: Approaching a new generation of phytopharmaceuticals

The longstanding, successful use of herbal drug combinations in traditional medicine makes it necessary to find a rationale for the pharmacological and therapeutic superiority of many of them in comparison to isolated single constituents. This review describes many examples of how modern molecular–biological methods (including new genomic technologies) can enable us to understand the various synergistic mechanisms underlying these effects.

Wagner, Hildebert. (2010). Synergy research: Approaching a new generation of phytopharmaceuticals. Fitoterapia. 82. 34-7. 10.1016/j.fitote.2010.11.016.

Beta-caryophyllene is a dietary cannabinoid

Gertsch J, Leonti M, Raduner S, Racz I, Chen JZ, Xie XQ, Altmann KH, Karsak M,Zimmer A. Beta-caryophyllene is a dietary cannabinoid.

Proc Natl Acad Sci U S A.2008 Jul 1;105(26):9099-104. doi: 10.1073/pnas.0803601105. Epub 2008 Jun 23.PubMed PMID: 18574142; PubMed Central PMCID: PMC2449371.

Neuroprotective Effects of β-Caryophyllene

Viveros-Paredes JM, González-Castañeda RE, Gertsch J, Chaparro-Huerta V, López-Roa RI, Vázquez-Valls E, Beas-Zarate C, Camins-Espuny A, Flores-Soto ME. Neuroprotective Effects of β-Caryophyllene against Dopaminergic Neuron Injury in a Murine Model of Parkinson’s Disease Induced by MPTP. Pharmaceuticals (Basel). 2017 Jul 6;10(3). pii: E60. doi: 10.3390/ph10030060. PubMed PMID: 28684694;PubMed Central PMCID: PMC5620604. 

Film forming systems for topical and transdermal drug delivery

Topical film forming systems are such developing drug delivery systems meant for topical application to the skin, which adhere to the body, forming a thin transparent film and provide delivery of the active ingredients to the body tissue. These are intended for skin application as emollient or protective and for local action or transdermal penetration of medicament for systemic action.The transparency is an appreciable feature of this polymeric system which greatly influences the patient acceptance. In the current discussion, the film forming systems are described as a promising choice for topical and transdermal drug delivery.

Kashmira Kathe, Harsha Kathpalia, Film forming systems for topical and transdermal drug delivery, In Asian Journal of Pharmaceutical Sciences, Volume 12, Issue 6, 2017, Pages 487-497, ISSN 1818-0876, 10.1016/j.ajps.2017.07.004.

Thin films as an emerging platform for drug delivery

Pharmaceutical scientists throughout the world are trying to explore thin films as a novel drug delivery tool. Thin films have been identified as an alternative approach to conventional dosage forms. The thin films are considered to be convenient to swallow, self-administrable, and fast dissolving dosage form, all of which make it as a versatile platform for drug delivery. This delivery system has been used for both systemic and local action via several routes such as oral, buccal, sublingual, ocular, and transdermal routes. Use of thin films is sometimes limited largely due to low drug loading capacity for a less potent drug given at high dose. Also, concerns for medication precision have been raised. CURE has solved for this.

Karki, Sandeep & Kim, Hyeongmin & Na, Seon-Jeong & Shin, Dohyun & Jo, Kanghee & Lee, Jaehwi. (2016). Thin films as an emerging platform for drug delivery. Asian Journal of Pharmaceutical Sciences. 11. . 10.1016/j.ajps.2016.05.004.

Oral Films: A Multi-Faceted Drug Delivery System And Dosage Form

Over the last decade, the science behind oral films has advanced significantly with improved methods for testing the purity, potency and uniformity of films, leading to greater investments and commercial viability.

This is an original white paper produced by CURE Pharmaceutical.

Davidson, Rob and Rousset, Jessica (2018). Oral Films: A Multi-Faceted Drug Delivery System And Dosage Form. OnDrugDelivery, Issue 88, July 9, 2018

Keywords: oral thin films, oral soluble films, oral dissolving films, oral dispersable films